Line Clearance Procedure varies from area to area and section to section but it is important to ensure that no left-over residues of previous product/unwanted material have been remained otherwise it shall be carried forward to the next product and leads to contamination.
It ensures that at all stages of manufacturing/granulation/dispensing/coating etc.. operations carried out before the start of operation / stage during the manufacturing/packing to avoid any contamination or mix ups of the previous product to the next product.
Visually check and ensure all the materials (utensil, tools, container, documents etc.) are removed from area, which were used in previous product.
Ensure the area for cleanliness & same should be cross verified with usage of cleaning logbook/records.
Ensure the temperature and relative humidity is within the specified limit as per mentioned in BMR.
Ensure that, the wall, panels, light, fixtures are cleaned in the respective area.
Ensure and check that the balances have calibration and status label.
Check the wash water analysis report.
Ensure that, previous stage of current batch has completed and reviewed by QA.
